The biologically active form of B12, used directly without conversion. Critical for neurological integrity, energy metabolism and normal homocysteine metabolism.
Why this form
Methylcobalamin is the biologically active form of B12 that requires no hepatic conversion — it is immediately available to the body and is the preferred choice for individuals with the MTHFR gene variant who may have impaired B12 processing.
Key benefits
Direct neurological support
As the active coenzyme form, methylcobalamin directly participates in methionine synthesis and neurological maintenance without requiring the liver conversion step that cyanocobalamin depends on.
Methylation & homocysteine
Methylcobalamin donates methyl groups in the remethylation of homocysteine to methionine, contributing to normal homocysteine metabolism.
MTHFR compatibility
For individuals with impaired MTHFR enzyme activity — affecting up to 40% of people — the active methylated form bypasses the conversion bottleneck, ensuring effective utilisation.
Supports