The bioavailable, methylated form of folate — bypasses the MTHFR enzyme step that affects up to 40% of the population. Critical for mood regulation, methylation and DNA integrity.
Why this form
Calcium L-5-methyltetrahydrofolate is the naturally active form of folate that bypasses the MTHFR enzyme — the conversion step that is genetically impaired in approximately 40% of the population — ensuring direct cellular availability regardless of genetic variation.
Key benefits
MTHFR-bypass bioavailability
Unlike folic acid, 5-MTHF does not require the MTHFR enzyme for activation. For the substantial proportion of people with reduced MTHFR activity, this is the only form of folate that reliably reaches tissues in active form.
Methylation & mood
5-MTHF is the methyl donor in pathways supporting normal neurotransmitter function. Adequate methylfolate status contributes to normal psychological function and mood.
DNA integrity & cell health
As the active cellular form of folate, 5-MTHF directly participates in DNA synthesis, repair and methylation — supporting genomic stability and the integrity of rapidly dividing cells.
Supports